Endocrine Abstracts

Introduction: Recombinant human IGF1 (rhIGF1) improves insulin sensitivity and glycaemic control when administered to people with diabetes. The effects of rhIGF1 on lipid metabolism in vivo are unclear.Objectives: To determine the effects of rhIGF1/rhIGFBP3 administration on fasting lipids, non-esterified fatty acids (NEFA) and glucose homeostasis in recreational athletes. This study was part of a randomised, double-blind, placebo-controlled trial...

Introduction: The incidence of the syndrome of inappropriate antidiuresis (SIAD) post pituitary surgery is estimated at 3-20% with the condition potentially leading to significant morbidity and prolonged admission. Copeptin, a surrogate marker for vasopressin activity, has been shown to be a diagnostic tool in the diagnosis of AVP deficiency (formerly known as diabetes insipidus) post pituitary surgery. There is limited data regarding the utility of copeptin in predicting SIAD...

Background: Diabetes insipidus (DI) is a recognised complication of pituitary surgery, with current diagnosis requiring clinical observation aided by plasma and urine electrolytes and osmolalities. Copeptin, a 39 amino acid glycopeptide secreted in equimolar quantities to ADH, is a stable surrogate marker of ADH release and has potential to facilitate prompt diagnosis of post-operative DI. This assay has been shown to accurately predict which patients are likely to develop DI ...

Introduction: GH is widely abused by athletes for its anabolic and lipolytic properties. As the tests for detecting GH abuse develop further, it is possible that athletes will exploit IGF1 as an alternative or additional doping agent. There is currently no evidence to suggest that IGF1 administration improves athletic performance.Objectives: To determine the effects of rhIGF1/rhIGFBP3 administration on body composition and physical fitness in recreationa...

The onset of human lactation is characterised by increased breast fullness and the start of copious milk secretion. The process, which typically occurs 1-4 days postpartum, is triggered by a decrease in serum progesterone and high prolactin concentrations, although the exact levels are ill-defined. We aim to establish reference intervals for hormones triggering the onset of sustained lactation and understand how breastfeeding influences hormone secretion, so as to improve the ...